
初春平,女,医学博士,三级教授,博士生导师,吉林省D类人才。1993年毕业于延边医学院,1996年获得延边大学医学院人体解剖学硕士学位并留校任教,1999年获得日本文部省奖学金赴日本宫崎医科大学留学,2004年获得医学生理学博士学位,并先后在日本宫崎大学和日本理化学研究所脑科学研究中做博士后,从事中枢对循环系统调节机制研究和小脑皮层信息传递机制研究。2009年人才引进回国工作,现任吉林医药学院基础医学院生理学教授。长期从事生理学、病理生理学和机能实验学的本科教学和神经生物学科研工作。研究了运动控制中枢小脑皮层感觉信息传递与整合机制,应用离体膜片钳结合单细胞RT-PCR和生物素染色研究了下丘脑室旁核神经元的活动及其影响机制,取得了一些科研成果。共发表SCI论文50余篇,主持国家自然科学基金4项,吉林省科技发展计划(自然科学基金)1项,获得吉林省自然科学学术成果二等奖2项,三等奖2项;已培养博士毕业生4人,硕士毕业生7人。兼任吉林省神经科学学会理事。
教育经历:
(1) 2000-4至2004-3, 宫崎医科大学, 生理学, 博士
(2) 1993-9至1996-6, 延边大学, 人体解剖学, 硕士
(3) 1988-9至1993-6, 延边医学院, 临床医学, 学士
科研与工作经历:
(1) 2021-11至现在, 吉林医药学院, 基础医学院, 生理学教授
(1) 2015-9至2021-10, 延边大学, 脑科学研究中心, 生理学教授
(2) 2009-9至2015-8, 延边大学, 脑科学研究中心, 生理学副教授
(3) 2006-4至2009-9, 日本理化研究所, 脑科学研究中心, 博士后
(4) 2004-4至2006-3, 日本宫崎大学, 医学部, 博士后
(5) 1999-1至2009-8, 延边大学, 医学院, 讲师
(6) 1996-7至1998-12, 延边大学, 医学院, 助教
科研项目:
1.国家科技创新2030重大项目子项目,2021ZD0202300,大脑皮层神经细胞多样性的发育机制,2021.12 至2026.12,382.5万元,在研,参加。
2.国家自然科学基金委员会,面上项目,32171005,蓝斑-小脑皮层去甲肾上腺素能投射调制感觉信息处理与运动协调机制,2022-01至2025-12,58万元,在研,主持。
3.国家自然科学基金委员会,地区基金项目,31760273,肾上腺素能受体在小鼠小脑皮层感觉信息处理和运动调节中的作用,2018-01至2021-12,39万元,已结题,主持。
4.政府间国际科技创新合作重点专项,2016YFE0128600,小脑神经环路的感觉信息处理与运动调节机制研究, 2017-01至2019-12,160.8万元,已结题,参加。
5.国家自然科学基金委员会,地区基金项目,31560272,神经内分泌调节肽对大鼠下丘脑室旁核神经元活动及突触传递的影响,2016-01至2019-12,38万元,已结题,主持。
6.国家自然科学基金委员会,地区基金项目,31260245,小鼠小脑外侧核谷氨酸能和GABA能神经元对感觉刺激反应的突触机制,2013-01至2016-12,60万元,已结题,主持。
7.吉林省科技发展计划,自然科学基金,20150101070JC,自然感觉刺激诱发小鼠小脑平行纤维-中间神经元间突触可塑性及其机制的研究,,2015.01至2017.12,10万元,已结题,主持。
发表论文:
1.Wang JY, Weng WC, Wang TQ, Liu Y, Qiu DL, Wu MC,Chu CP*. Noradrenaline depresses facial stimulation-evoked cerebellar MLI-PC synaptic transmission via α2-AR/PKA signaling cascade in vivo in mice.Sci Rep. 2023 Sep 23;13(1):15908.
2.Cui LN, Zhang XD, Xu YH, Li BY, Qiu DL,Chu CP*. Activation CRF-R2 augments cerebellar climbing fiber-Purkinje cell synaptic transmission via presynaptic PKA pathway in mice. Neuroscience Letters 777 (2022) 136584.
3. Li BX, Jin H, Zhang GJ, Cui LN,Chu CP*, Qiu DL *. Effect of Noradrenaline on the Facial Stimulation-Evoked Mossy Fiber-Granule Cell Synaptic Transmission in Mouse Cerebellar Cortex.Front Neurosci. 2021; 15: 785995.
4.Cui LN, Sun N, Li BX, Wang LF, Zhang XY, Qiu DL,Chu CP*. Noradrenaline inhibits complex spikes activity via the presynaptic PKA signaling pathway in mouse cerebellar slices. Neurosci Lett. Volume 729, 11 June 2020, 135008
5.Sun N, Li BX, Dong GH, Li DY, Cui BR, Qiu DL, Cui SB,Chu CP*. Chronic ethanol exposure facilitates facial-evoked MLI-PC synaptic transmission via nitric oxide signaling pathway in vivo in mice. Neurosci Lett. 2020 Jan 10;715:134628.doi: 10.1016/j.neulet.2019.134628. Epub 2019 Nov 16.
6.Sun N, Li BX, Hong YJ, Bing YH, Qiu DL,Chu CP*. Noradrenaline depresses spontaneous complex spikes activity of cerebellar Purkinje cells via α2-adrenergic receptor in vivo in mice. Neurosci Lett. 2019 Jun 11;703:38-44.
16.Wu MC, Bing YH,Chu CP*, Qiu DL*. Ethanol modulates facial stimulation-evoked outward currents in cerebellar Purkinje cells in vivo in mice. Sci Rep. 2016 Aug 4;6:30857.
17.Liu H, Lan Y, Bing YH,Chu CP*, Qiu DL*. N-methyl-D-Aspartate Receptors Contribute to Complex Spike Signaling in Cerebellar Purkinje Cells: An In vivo Study in Mice. Front Cell Neurosci. 2016 Jun 30;10:172.
18.Guo A, Feng JY, Li J, Ding N, Li YJ, Qiu DL, Piao RL*,Chu CP*. Effects of norepinephrine on spontaneous firing activity of cerebellar Purkinje cells in vivo in mice. Neurosci Lett. 2016 Aug 26; 629: 262–266
19.Jin WZ, Liu H, Wan P,Chu CP*, Qiu DL*.Propofol enhances facial stimulation-evoked responses in the cerebellar granule cell layer via NMDA receptor activation in mice in vivo. Eur J Pharmacol. 2016 Jun 14;788:37-44.
21.Ding N, Jin H, Zhang BB, Guo A, Shi JD, Feng JY, Li J, Shen XX, Shi Y, Qiu DL*,Chu CP*. Anatomical and functional relationships between deep cerebellar nuclei and cerebellar cortical Crus II in vivo in mice. Neurosci Lett. 2016 Jan 1; 610 : 73-78.
22.Jin WZ, Shi JD, Liu H, Lan Y,Chu CP*, Qiu DL*. Effects of Propofol on the Dynamic Properties of Sensory Information Processing in the Mouse Cerebellar Cortical Molecular Layer in vivo. Pharmacology. 2015 Oct 22;96(5-6):271-277.
23.He YY, Jin R, Jin WZ, Liu H,Chu CP*, Qiu DL*. Propofol facilitates excitatory inputs of cerebellar Purkinje cells by depressing molecular layer interneuron activity during sensory information processing in vivo in mice. Neuroreport. 2015 Oct 21;26(15):921-7.
24.Jin R, Liu H, Jin WZ, Shi JD, Jin QH,Chu CP*, Qiu DL*. Propofol depresses cerebellar Purkinje cell activity via activation of GABAA and glycine receptors in vivo in mice. European Journal of Pharmacology. 764 (2015) 87–93.
25.Bing YH, Wu MC,Chu CP*, Qiu DL*. Facial stimulation induces long-term depression at cerebellar molecular layer interneuron–Purkinje cell synapses in vivo in mice. Front Cell Neurosci. 2015 Jun 9;9:214 .
26.Bing YH, Jin WZ, Sun L,Chu CP*, Qiu DL*. Effect of gabazine on sensory stimulation train evoked response in mouse cerebellar Purkinje cells. Pharmazie 70: 129–134 (2015).
27.Chu CP, Cui BR, Kannan H, Qiu DL. Alterations in the Baroreceptor-heart Rate Reflex in Conscious Inbred Polydipsic (STR/N) Mice. Physiol Res. 2015 May 20;64(2):173-82. Epub 2014 Oct 15.
28.Bing YH, Zhang GJ, Sun L,Chu CP*, Qiu DL*. Dynamic properties of sensory stimulation evoked responses in mouse cerebellar granule cell layer and molecular layer.Neurosci Lett. 2015 Jan 12;585:114-8.
29.Cui SB, Cui BR, Liu H, Wu MC, Xu YH, Bian JH,CP Chu *, Qiu DL*. Effects of ethanol on sensory stimulus-evoked responses in the cerebellar molecular layer in vivo in mice. Neurosci Lett. 2014 577(8): 112-116.
30.Chu CP, Zhao GY, Jin R, Zhao SN, Sun L and Qiu DL*. Properties of 4Hz stimulation induced parallel fiber-Purkinje cell presynaptic long-term plasticity in mouse cerebellar cortex in vivo. Eur J Neurosci 2014 May;39(10):1624-31.
31.Liu H, Zhao GY, Zhao SN, Sun L,Chu CP*, Qiu DL*; N-methyl-d-aspartate inhibits cerebellar Purkinje cell activity via the excitation of molecular layer interneurons under in vivo conditions in mice. Brain res 2014, Apr 29;4:1-9.
32.Wu G, Liu H, Jin J, Hong L, Lan Y,Chu CP* and Qiu DL*. Ethanol Attenuates Sensory Stimulus-Evoked Responses in Cerebellar Granule Cells via Activation of GABAA receptors in vivo in Mice. Neurosci Lett. 2014 Feb 21;561:107-11. (This work was selected key article on Global Medical Discovery, www.globalmedicaldiscovery.com)
33.Jin R, Li MZ, Bing YH, Piao RL, Li YJ, Jin QH, Qiu DL*, Kannan H,Chu CP*. Intracerebroventricular injection of stresscopin-related peptide enhances cardiovascular function in conscious rats. Regul Pept. 2013 Sep 10;186:7-11.
34.Chu CP, Jin WZ, Bing YH, Jin QH, Kannan H, Qiu DL. Effects of stresscopin on rat hypothalamic paraventricular nucleus neurons in vitro. PLoS One. 2013;8(1):e53863.
35.Chu CP, Bing YH, Liu H and Qiu DL. Roles of Molecular layer Interneurons in Sensory Information Processing in Mouse Cerebellar Cortex Crus II. PlosONE 2012, 7(5): e37031. (This work was selected key article on Global Medical Discovery, www.globalmedicaldiscovery.com) and was recommended on Pubadvanced).
36.Chu CP, Xu CJ, Kannan H and Qiu DL. Corticotrophin-releasing factor inhibits neuromedin U mRNA expressing neuron in the rat hypothalamic paraventricular nucleus in vitro. Neurosci Lett. 2012, 511(2):79-83.
37.Chu CP, Bing YH, Liu QR and Qiu DL. Synaptic Responses Evoked by Tactile Stimuli in Purkinje Cells in Mouse Cerebellar Cortex Crus II In Vivo. PLoS One. 2011; 6(7): e22752。
38.Chu CP, Bing YH and Qiu DL. Sensory Stimulus Evokes Inhibition rather than Excitation in Cerebellar Purkinje Cells in vivo in Mice. Neurosci Lett 2011, 487:182-6.
39.Chu CP, Kannan H and Qiu DL. Effect of hypertonic saline on rat hypothalamic paraventricular nucleus parvocellular neurons in vitro. Neurosci Lett 2010 482: 142–145.